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The endpoint algorithms were validated and showed a sensitivity of over 99% for mortality in the National Death Index, a positive predictive value of 94% for myocardial infarction, 95% for stroke and 98% for heart failure hospitalization 33,35,36,37,38,39,40
Similar to the periplasm, the GSH:GSSG ratio in the ER is lower (3:1 to 1:1) compared to the cytosol (100:1), resulting in a more oxidizing environment (Hwang et al., 1992)
Research shows that large portion sizes often lead to consuming more calories despite not being hungry
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