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Preclinical research in murine senescence models has examined FOXO4-DRI for its capacity to reduce senescent cell burden, with observed improvements in physical function, coat density, and renal histology endpoints in aged subjects

[4] [5] Patients experiencing symptoms potentially related to cortisol abnormalitiessuch as unexplained weight gain (particularly central obesity), persistent fatigue, muscle weakness, easy bruising, or mood changesshould undergo appropriate evaluation before attributing these to metabolic syndrome alone

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Many participants even saw a slight reduction in their body mass index (BMI)