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The Endocrine Society's 2016 clinical practice guideline on GH deficiency in children states: "Monitoring of IGF-1 levels is recommended every 6 months and should be maintained within the normal range for age and sex to minimize potential risks." [7] That standard applies directly to sermorelin-treated adolescents, since the downstream outcome (IGF-1 elevation) is the same regardless of whether GH is given directly or stimulated endogenously

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