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For instance, in the pivotal SURPASS-2 trial, patients receiving the highest tirzepatide dose (15 mg) achieved a mean body weight reduction of 11.2 kg, nearly twice that observed with semaglutide 1 mg (5.7 kg) (19)
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The American Association of Clinical Endocrinology advocates for improved access to these evidence-based therapies, particularly for patients with cardiovascular disease or obesity-related complications where clinical benefits are well-established
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