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It is contraindicated in patients with an estimated glomerular filtration rate (eGFR) below 30 mL/min/1.73 m, should not be initiated in patients with an eGFR between 30-45 mL/min/1.73 m, and requires at least annual monitoring of renal function
Most gastrointestinal symptoms are mild to moderate in severity and often improve over time as the body adjusts to the medication
Pregnancy increases the need for nutrients During pregnancy, macronutrient intake needs grow significantly
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