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ESG and Reputational Risk Pfizer must maintain trust given it sells products that affect health
Rinella ME, Neuschwander-Tetri BA, Siddiqui MS, Abdelmalek MF, Caldwell S, Barb D, Kleiner DE, Loomba R
The diminished DNA antioxidative defense of the body leads to an intensified attack of free radicals on DNA molecules and finally to the development of malignant diseases (Ames, 1989)
It competitively binds p53, displacing endogenous FOXO4 in senescent cells (Baar et al., 2017) 24-72 hours: Freed p53 translocates to mitochondria in senescent cells, triggering the intrinsic apoptotic cascade
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