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When estradiol levels rise due to fat-driven aromatization or conversion of excess external testosterone the brain senses enough sex hormone and slows down the axis: Less GnRH is released from the hypothalamus The pituitary releases less LH and FSH The testes produce less natural testosterone This negative feedback loop means men with obesity or on high-dose TRT may experience further suppression of their own testosterone production and long-term dependence on therapy

As we age, mitochondrial efficiency naturally changes

Krner M, Waser B, Christ E et al (2017) A critical evaluation of sst3 and sst5 immunohistochemistry in human pituitary adenomas

Gender differences in the effect of a 0.11% breath alcohol concentration on forward and backward gait