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In clinical trials, patients lost an average of 26% body weight during 88 weeks

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Gene expression studies using microarray analysis reported that GHK-Cu at low nanomolar concentrations influenced the expression of over 4,000 human genes in fibroblast models, including upregulation of collagen I, collagen III, and elastin synthesis, and modulation of matrix metalloproteinase activity (Pickart and Margolina, Symmetry 2018)

Available at: [accessed March 2026]. Once-weekly semaglutide in adults with overweight or obesity (STEP 1) structured abstract and commentary