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Mitochondrial dysfunction caused by the significant increase of ROS, resulting in LPO and inhibition of respiratory chain (complexes I and III) triggering apoptosis, which may explain the hepatotoxicity caused by statins (Figure 3) [143]
Because weight loss is central to every management guideline, but very hard to achieve and maintain, the rise of GLP-1 RAs, which consistently help with weight loss and may also directly lower intracranial pressure, raised the question of whether they could contribute to treatment
Pre-surgical (pre-habilitation) phase: For patients with existing soft tissue or joint pain (e.g., knee, shoulder) entering surgery, PDA may help reduce baseline pain and improve tissue condition, which in turn could help improve pre-operative mobility and strength
We must acknowledge that our experience with these weight loss drugs is limited, and tens of millions of people may be exposed to their unforeseen effects for decades
