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Fick, M
Tirzepatide is designed to be increased gradually
If it remains cloudy after 10 minutes of gentle swirling, something is wrong
The rate shows a clear dose-response pattern: in the SURMOUNT-1 trial published in the New England Journal of Medicine (N=2,539 adults followed for 72 weeks), reported rates climbed from roughly 12% at the 2.5 mg starting dose to 23% at the 15 mg top dose, compared to about 8% on placebo
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