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Karlsson, T., Hadizadeh, F., Rask-Andersen, M., Johansson, & Ek, W

These approaches enable precise delivery of nucleic acid cargo (siRNA, miRNA, plasmids encoding non-coding RNAs, etc.) to injured renal tissue, allowing modulation of transcriptional networks, silencing of pathogenic genes, and reprogramming of cellular metabolism and inflammatory responses.Platelet membranemimicking nanoparticles (PMVs@PLGA) carrying TGF-1 siRNA utilize the natural homing ability of platelet membranes to damaged vasculature, selectively silencing the TGF-1/Smad3 pathway, reducing collagen deposition and inflammatory cytokine release in UUO and IRI models, and avoiding systemic off-target effects [98]

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Hemodialysis (HD) in chronic renal failure (CRF) does not produce carnitine (c) depletion [abstract]