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While Rybelsus can contribute to weight loss, its primary purpose is to help manage blood sugar levels in diabetes patients
After discontinuation, most regain significant weight often reversing most of what they initially lost
GLP-1 receptors are present in brain regions involved in appetite regulation, reward pathways, and potentially pain modulation
Considerable overlap was, however, observed between VNUT and GLP-1 in primary mouse (mean SEM: 40 6% of VNUT + ve staining positive for GLP-1, n = 19 cells) and human (54 7% of VNUT + ve staining positive for GLP-1, n = 17 cells) L-cells and this was even more pronounced when co-staining for PYY was analysed (91 3% ( n = 19) and 91 4% ( n = 18) of VNUT + ve staining cells also stained positive for PYY in mouse and human, respectively)
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