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This dual formulation has been studied in research for its effects on cellular signaling, peptide interaction models, and receptor studies

Marques, Natlia Nunes, Bruno Paulo Rodrigues Lustosa, Daniel Wagner Castro Lima Santos, Flvio Queiroz-Telles, Sybren de Hoog, Renata R

Nevertheless, their therapeutic potentials are still subject of debate, particularly given their known gastrointestinal side effects (e.g., nausea, vomiting, and diarrhea), which may limit their application in IBD patients, especially those with clinically active disease (14)

[8] It is generally less preferred than metformin or sulfonylureas