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344 Iron overload may trigger an inflammatory response through activating the NF-B pathway and inducing the secretion of inflammatory factors such as IL-1, TNF-, and IL-6
Among the compounds we screened, 37 compounds (such as quercetin, afzelin, puerarin, geniposide, etc) promote melanocyte generation through the above pathways (Figure 2)
This analysis identified 183 enriched biological processes, including response to hypoxia, positive regulation of apoptosis, IL-1 production, response to hydrogen peroxide, and heart development
For example, a study that looked at genetic differences in a group of 192 individuals who took 4 g/day of acetaminophen found that variants that decreased sulfation (specifically in the SULT1E1 gene) were more likely to have elevated liver enzymes
