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GLP-1 (Glucagon-Like Peptide-1): This hormone signals the brain to reduce appetite and "food noise"
In addition to dopaminergic neuronal loss in the SN and the onset of motor symptoms in PD, these changes cause microgliosis, mitochondrial failure, oxidative stress, and inflammation
Beyond weight loss, tirzepatide also demonstrated significant improvements in fasting insulin, blood pressure, lipid profiles, and overall glycaemic control, reinforcing its potential role in long-term metabolic health management
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