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253 These limitations stem from the pleiotropic nature of upstream signaling pathways and their network-level crosstalk, which diminishes the efficacy of monotherapeutic approaches targeting cardiac remodeling

GLP-1 receptors are expressed in key reward-related brain regions , including: The ventral tegmental area (VTA) and nucleus accumbens , which form the core of the mesolimbic dopamine pathway The prefrontal cortex , involved in executive function and impulse control The amygdala , which processes emotional salience and stress responses The prevailing hypothesis suggests that GLP-1 receptor activation may modulate dopamine signalling in reward circuits

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World J Biol Chem 8(1):86