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Like many metabolic therapies, dosing typically begins low and increases gradually over time to improve tolerability and support long-term progress
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The combination addresses both limitations simultaneously
136 In a randomized controlled trial in 66 participants with mild-to-moderate sleep disorders related to anxiety, subjective measures of time needed to fall asleep, sleep duration, and sleep quality improved in those given 15.5 mg saffron extract daily for six weeks, but not in those given placebo
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