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The key molecular pathway identified involves the activation of the general control nonderepressible 2 (GCN2) kinase, leading to the phosphorylation of eukaryotic initiation factor 2 alpha (eIF2) and the upregulation of ATF4
Michael Levin, PhD, FRCPCH 15
In diet-induced obese (DIO) mouse models, GCGR activation was found to contribute approximately 3035% of the total body-weight-lowering effect through increased energy expenditure, while GIPR and GLP-1R activity contributed to caloric-intake reduction
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