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-Ketoglutarate improves cardiac insufficiency through NAD(+)-SIRT1 signaling-mediated mitophagy and ferroptosis in pressure overload-induced mice
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However, there is another gene more directly associated with sulfur intolerance: cystathionine beta-synthase (CBS)
Lower thresholds likely exclude individuals without pauses in medication, whereas higher thresholds more likely relate to the actual dosage that individuals receive (i.e., those with no pauses but receiving low-to-intermediate doses are excluded with these thresholds)
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