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Marked interindividual heterogeneity exists in platinum accumulation and toxicity severity among patients with similar cumulative doses, which is mainly mediated by genetic polymorphisms (e.g., GSTP1), epigenetic modifications, and baseline health status
Start by eating cruciferous vegetables like broccoli, cauliflower, and Brussels sprouts
Adults need 2.4 micrograms (mcg) daily, with slightly higher amounts during pregnancy or chestfeeding
IGF1R autophosphorylation also recruits Shc, which leads to Grb2/SOS/Ras activation and downstream ERK1/2 phosphorylation
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