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M1 macrophages are activated by CS, bacterial products, and DAMPs, and secrete pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-) and interleukin-6 (IL-6) (87)
We thank an anonymous referee for pointing out the hypothesis regarding Hcy transport out of the cell to avoid toxicity
The exact reason for this is not yet understood
There are a number of different group therapy modalities, including support groups, experiential therapy, psycho-education, and more
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