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The FDA guidelines work in both directions, covering both late and early dosing scenarios
However, it is important to note that: Clinical trials have limitations in detecting rare adverse events, particularly those that may take extended periods to develop Post-marketing surveillance continues to monitor for previously unidentified safety concerns Individual case reports may emerge, but these do not establish causation without rigorous epidemiological analysis Why the question arises : The association between Wegovy and diverticulitis may be questioned because: Gastrointestinal effects : Wegovy commonly causes GI side effects including nausea, constipation, and changes in bowel habits, which might theoretically affect colonic function
Association between Different GLP-1 Receptor Agonists and Gastrointestinal Adverse Reactions: A Real-World Disproportionality Study Based on FDA Adverse Event Reporting System Database. Frontiers in Endocrinology, vol
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