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with VIP (Vasoactive Intestinal Peptide), which has potent anti-inflammatory, neuroprotective, and immune-modulating effects
Either Trx and TrxRD are expressed as isoforms for both predominantly cytosolic (Trx1 and TrxRD1) or mitochondrial (Trx2 and TrxRD2) localization (Orrenius et al., 2007)
These differences matter clinically: larger average weight loss translates into bigger improvements in blood pressure, glycemic measures, sleep apnea metrics, mobility, and quality of life for many patients
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