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It is not medical advice and should not be used to diagnose, treat, or prevent any condition

Contrave side effects The most common side effects include: Nausea Constipation Diarrhea Headache Vomiting Dizziness Insomnia Dry mouth Rare but serious side effects include an allergic reaction, seizures, liver damage, increased blood pressure or heart rate, and vision problems

For instance, a high acetyl-CoA/CoA ratio in the mitochondrial matrix inhibits pyruvate dehydrogenase (PDH) that catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA (Pietrocola et al., 2015)

In the research community, sustained or supraphysiologic IGF-1 exposure is associated with progressive abdominal distension (sometimes called 'GH gut') and concern for cardiac hypertrophy