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Because they act through non-overlapping receptor systems one via the GHRH/pituitary/IGF-1 axis, the other via GLP-1/GIP/glucagon receptors researchers frequently combine them in comparative body-composition models to observe complementary effects on visceral fat and lean mass preservation
While semaglutide works by mimicking a natural hormone (GLP-1) that slows digestion and reduces appetite, tirzepatide goes a step further by targeting both GLP-1 and GIP receptors , offering even more powerful appetite control and metabolic support
This is not just academic detail
PMC8089287 Alissou O, et al
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