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The BBB and BSCB are essential in maintaining CNS homeostasis by controlling the selective passage of molecules, ions, and cells, thus safeguarding neuronal function and CNS integrity
This absorption pattern has a direct implication for early dosing
Although they appropriately used inverse probability of treatment weighting to control for confounding, this approach does not ensure clinical equipoise, limiting causal interpretation because the comparison includes patients who may never have been appropriate candidates for treatment
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