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The Impact of Statin Therapy and Aerobic Exercise Training
Relevant for clinical practice, our findings show that treatment with semaglutide lowered the risk of MACE compared to sitagliptin, while tirzepatide showed at least comparable benefit to dulaglutide, an older GLP-1 receptor agonist with established cardiovascular efficacy
Coverage for weight loss is a different story: only 13 states cover obesity-indicated GLP-1s as of January 2026, and that number has been shrinking as states face budget pressure
Most patients tolerate treatment very well, but some may experience nausea, constipation, bloating, or fatigue during the first few weeks
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