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Obesity is linked to increased risk of HF incidence, particularly HFpEF ( 3.5 Effects on arrythmia GLP-1 RAs were associated with a significant reduction in all-cause mortality and CV mortality, and did not increase the risk of sudden cardiac death, atrial arrythmias, or ventricular arrhythmias in T2DM patients ( 3.6 GLP-1 RAs in clinical practice The cardioprotective properties of GLP-1 RAs seem to be mediated through CV risk factors modification
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Leucovorin appears to offer a way around that metabolic roadblock
It should not be used in neonates, pregnant women, certain medications, or for intrathecal injection
