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Watch-outs to know: The FDA has flagged Semax as a peptide that might trigger an unwanted immune response, and it has raised concerns about impurity and lack of safety data in humans

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5-Lipoxygenase - a key enzyme: The biosynthetic precursor of the leukotrienes is arachidonic acid released mainly from phosphatidylinositol and polyphosphoinositides by the action of phospholipase A 2 (cPLA 2 ), and this is acted upon by enzymes located at the endoplasmic reticulum (ER) or nuclear membrane, each of which has a high stereospecificity, starting with 5-lipoxygenase (5LOX, ALOX5) (see our web page on mono-hydroxyeicosatetraenes for a discussion of lipoxygenases in general)