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Hsu TM, Hahn JD, Konanur VR, Lam A, Kanoski SE
Their primary mechanisms of action include: Enhancing insulin secretion from pancreatic beta cells in a glucose-dependent manner, which generally reduces the risk of hypoglycaemia (though this risk increases when combined with insulin or sulfonylureas) Suppressing glucagon release from pancreatic alpha cells, thereby reducing hepatic glucose production Slowing gastric emptying , which prolongs satiety and reduces postprandial glucose excursions Acting on appetite centres in the hypothalamus to reduce hunger and food intake These combined effects lead to improved glycaemic control in people with type 2 diabetes and significant weight reduction in those prescribed these medications for obesity management
European regulators reached the same conclusion in 2023 after reviewing available research on GLP-1s
Its a carefully formulated approach to a complex problem
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