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Patient selection considerations include: Adults with BMI 30 kg/m or 27 kg/m with weight-related comorbidities [1] [7] Contraindications must be carefully reviewed, including personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 History of pancreatitis, gallbladder disease, severe gastrointestinal disease, or renal impairment requires caution Not recommended during pregnancy or lactation Clinicians should counsel patients that while inflammatory marker improvements have been observed in research settings, Zepbound is prescribed for weight management, not inflammation treatment

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The Role of Leptin-Melanocortin System and Human Weight Regulation: Lessons from Experiments of Nature