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Mitochondrial problems were present as early as P15 (postnatal day 15) 17 , and they were also observed in the upper motor neurons (UMNs) of a broad spectrum of ALS patients with TDP-43 pathology 16

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Excess cysteine and methionine are oxidized to sulfate and excreted in the urine or stored as glutathione

Hydrolysis of phosphatidylcholine by specific enzymes produces molecules like lysophosphatidylcholine (LPC) and diacylglycerol (DAG), which are involved in intracellular signaling processes