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DOI: 10.14740/jem211w Kwon DR & Park GY (2015) Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model Ann Clin Lab Sci 45(4):426432
By using B12 instead of just corticosteroids, patients benefit from reduced side effects without compromising effective pain relief
There is no published long-term human safety data, no completed RCT, and the most-cited theoretical concern remains angiogenesis in the context of undiagnosed cancer
Conservative protocols starting at 0.25 mg daily suit first-time users and those with minor injuries
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