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Vitamin B12 is an essential nutrient involved in red blood cell formation, neurological function, DNA synthesis, and cellular energy metabolism

Bioavailability refers to the proportion of a substance that enters the circulation when introduced into the body

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We found that glutathione and thioredoxin, the major thiol antioxidants, and glutathione and thioredoxin reductases, the enzymes responsible for maintaining them in a reduced state, fell substantially in rodent bone marrow after ovariectomy and were rapidly normalized by exogenous 17- estradiol