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Activation of POMC neurons leads to the release of alpha-melanocyte-stimulating hormone (-MSH), which subsequently binds to the melanocortin 4 receptor in the paraventricular nucleus of the hypothalamus and triggers appetite-inhibiting signaling cascade
12(7):10901100.e2
[4] [3] Without adequate B12, nerve signals cannot transmit efficiently, potentially leading to neurological symptoms such as tingling, numbness, or balance problems
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