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But retatrutide (LY3437943) backed up the hype with numbers no obesity drug has matched: 24.2% average body weight reduction at the highest dose in just 48 weeks, published in the *New England Journal of Medicine* by Jastreboff et al

Neurobiological Mechanisms and Therapeutic Potential of Glucagon-like Peptide-1 Receptor Agonists in Binge Eating Disorder: A Narrative Review

The downstream health savings from that magnitude of weight loss include: | Potential Savings | Annual Value | |-------------------|-------------| | Reduced diabetes risk/medications -- see [GLP-1 comparison chart](/guides/glp1-medications-comparison-chart-guide) for all options | $2,000-6,000 | | Blood pressure medication reduction | $600-1,800 | | Sleep apnea treatment reduction | $1,200-3,600 | | Avoided bariatric surgery | $20,000-35,000 (one-time) | | Reduced joint replacement risk | $30,000-50,000 (lifetime) | Against a first-year cost of $3,000-5,500 for compounded retatrutide, the financial case is strong for patients who respond well

Retatrutide 20mg The bulk research format of retatrutide Eli Lilly's groundbreaking triple receptor agonist providing the largest available quantity for high-throughput metabolic studies or extended longitudinal protocols