Frequency depends on your needs and provider recommendations
It is possible, perhaps likely, that studies return lower effect sizes if they are conducted among people from Western, Educated, Industrialised, Rich and Democratic countries (WEIRD, Henrich et al., Reference Henrich, Heine and Norenzayan2010), not least because WEIRD people are also ODD that is, they are relatively old, and live in deodorised and desensitised conditions (Roberts et al., Reference Roberts, Havlek and Schaal2020a)
Similar functions have been reported in Strongylocentrotus intermedius under low-salinity stress, where sphingosine-1-phosphate metabolism, was implicated in preventing apoptosis 27
This type of anemia is caused by a lack of the intrinsic factor needed to support red blood cell production