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R-2-HG Wild-type IDH1 and IDH2 catalyze the reaction by converting isocitrate and NADP + into -KG and CO 2 with the concomitant generation of NADPH in the cytosol and mitochondrial matrix

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Adults require 700 milligrams daily, ideally obtained through dietary sources such as dairy products, fortified plant milks, leafy greens, and tinned fish with bones

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