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cerevisiae strains C3G1-C3G10 and DHQC3G1DHQC3G10 (Supplementary Table 5) were restreaked on SC-ULH plates (1.47 g l 1 Synthetic Complete (Kaiser) Drop Out: Leu, His, Ura, 6.7 g l 1 yeast nitrogen base (without amino acids), 20 g l 1 d-(+)-glucose, 16 g l 1 agar) or SC-U plates (SC-ULH, 380 mg l 1 leucine, 76 mg l 1 histidine), respectively

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Tensiometry investigation took place by measuring the tensile breaking force and relative elongation of the damaged skin immediately after euthanasia and at days 7 and 14

(2) Incidence and Severity Research: Several cohort studies show that the incidence of high altitude illnesses (such as Acute Mountain Sickness, Chronic Mountain Sickness, High Altitude Pulmonary Edema, and High Altitude Cerebral Edema) increases with rising altitude and exhibits significant individual variability (Wang et al., 2014)