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Glutathione depletion as a consequence occurs in: active chronic infection (Epstein-Barr reactivation, chronic hepatitis B/C, HIV, tuberculosis, Lyme co-infections), uncontrolled diabetes with HbA1c above 8.5%, ongoing heavy metal exposure (occupational, dental amalgam in symptomatic individuals, contaminated water), persistent mold biotoxin exposure, untreated obstructive sleep apnea with nocturnal hypoxia, and chronic NSAID, acetaminophen, or alcohol use

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GLP-1 agonists (semaglutide, tirzepatide) reduce appetite and slow gastric emptying to create caloric deficits, while AOD-9604 and 5-Amino-1MQ directly enhance fat mobilisation and oxidation without affecting satiety signalling

However, the intervention period in the present study was relatively short