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185 SIRT1 is essential for controlling ROS production, maintaining mitochondrial function, and regulating selective autophagy
renal impairment may require monitoring The one-week half-life of both components enables true once-weekly dosing while maintaining relatively stable plasma concentrations throughout the dosing interval, contributing to consistent therapeutic effects and potentially improved tolerability compared to shorter-acting agents
doi:10.3389/fgene.2021.652704
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