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Curcumin can reverse insulin resistance or protect RINm5F pancreatic cells from apoptosis induced by nortriptyline by inhibiting the phosphoinositide 3-kinase/AKT/FOXO1 pathway and AKAP150/PKA/PP2B interaction, acting on diabetes caused by antidepressants
[54] in women with PCOS, BMI 25 kg/m 2 and/or insulin resistance, treatment with liraglutide 1.8 mg/day for 26 weeks, along with a higher weight loss, induced significant reductions in fasting plasma glucose, HbA1c, and plasma glucose AUC, whereas Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), Matsuda index and insulin AUC remained unchanged
That was my biggest downfall. Nature 638 , 308-310 (2025) doi: References Jastreboff, A
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