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Furthermore, increased TRPV2 palmitoylation in the brains of AD mice inhibits A phagocytosis in microglia, accompanied by a decrease in their phosphorylation levels, suggesting that the tyrosine phosphorylation cycle and the cysteine palmitoylation cycle have opposing effects on transient receptor potential vanilloid 2 (TRPV2) channel-mediated A phagocytosis in microglia (172)