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Studies of excess APAP-stimulated mouse and human primary hepatocytes have found very rapid, intense, and sustained activation of EGF receptor (EGFR) in the early stage of injury, which are possibly triggered by GSH depletion, after which levels of a series of toxicity markers begin to rise, and activation of EGFR signaling may contribute to late liver regeneration [247]
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Development and evaluation of C10 and SNAC erodible tablets for gastric delivery of a GIP/GLP1 peptide in monkeys
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