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The four components span distinct structural classes and non-overlapping pathway layers: BPC-157 for angiogenic and growth-factor signaling, GHK-Cu for copper-mediated extracellular-matrix and collagen biology, TB-500 (Thymosin Beta-4) for actin-driven cell migration, and KPV (the C-terminal -MSH fragment) for NF-B and inflammatory-cytokine modulation
Cait and colleagues 1 used transgenic mice that selectively deletes Podxl in vECs ( Podxl Tie2 DEC ) to study the role of this protein in maintaining the BBB during acute inflammation
He mentioned this along with supposed suppression of stem cells
The bounds of the parameter values are given in supplementary Table S2
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