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Arterburn DE, Telem DA, Kushner RF, et al

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Similarly, after bariatric surgery, fasting plasma total bile acid levels and 6-hydroxylated bile acids (agonists of TGR5) increase, whereas fecal bile acid excretion decreases, suggesting enhanced bile acid reabsorption and activation of TGR5 [68]

Retatrutide (development code LY3437943) is a 39-amino acid synthetic peptide developed by Eli Lilly as the first triple-receptor agonist targeting GLP-1R, GIPR, and GCGR in a single molecule