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Sleep deprivation and circadian disruption increase DPP-4 activity, reducing the effective lifespan of GLP-1 even when production is adequate
hdl:2433/215430
Robert A Koeth, Zeneng Wang, Bruce S Levison, Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis, 2013 Judith L Flanagan, Peter A Simmons, Role of carnitine in disease, 2010 .
Those positive estimates also rest largely on the early-phase studies, and the single most heavily weighted Phase 3 result, the null Exenatide-PD3 trial, argues against a robust class-wide effect
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