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Additionally, it reduces the mRNA levels of proinflammatory cytokines, such as interleukin-1 (IL-1), interleukin-6 (IL-6), and interleukin-12 (IL-12), both in muscle tissue in vivo and in adipose tissue cells in vitro , thereby alleviating high-fat diet-induced obesity and insulin resistance (37, 38), consistent with the results of facilitating the reduction of skeletal muscle lipid deposition and enhancing adipose tissue lipolysis (39) (Figure 3C)

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0.46 g 0.32 g