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Nature 546 , 254258 (2017)

Conclusions As discussed above, the role of amino acids in supporting or inhibiting tumor biology and antitumor immune responses can be variable, depending on the tumor type, its mutations, infiltrated immune cells, the presence of other molecules, the biochemical conditions in the TME (oxygen levels, etc), and the metabolism of the cells from the TME, influencing, for example, how they use the amino acids, as a carbon source or as a substrate for enzymes or PTMs

Many researchers find that injection timing affects the severity of GI side effects

Meanwhile, those at risk for certain cancers are more interested in lowering their levels (5, 7, 8)