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When medication is appropriate, orlistat represents an alternative pharmacological option available on the NHS, though it also carries gastrointestinal side effects (including oily stools and faecal urgency) due to its mechanism of inhibiting fat absorption
These obstacles exist despite broad recognition of GLP-1 efficacy
As with many peptides, that interest tends to run ahead of the evidence
in Italy assessed the efficacy of a hydrolyzed collagen supplement (5 g per day) to improve skin moisturization, elasticity, and the appearance of wrinkles in 52 women (4060 years of age), where 26 women received the supplement and 26 women were given a placebo for a total of 56 days [41]
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